Differential effects of testosterone on protein synthesis activity in male and female quail brain

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• 作者：Dermon ; C. R. ; Stamatakis ; A. ; Giakoumaki ; S. ; Balthazart ; J.
• 关键词：sexual dimorphism ; medial preoptic nucleus ; leucine incorporation ; sex behavior ; sex difference ; Aid ; archistriatum pars dorsalis ; AIv ; archistriatum pars ventralis ; AL ; ansa lenticularis ; ANOVA ; analysis of variance ; AR ; androgen receptor ; CCM ; cloacal c
• 刊名：Neuroscience
• 出版年：2004
• 出版时间：2004
• 年：2004
• 卷：123
• 期：3
• 页码：647-666
• 全文大小：751 K

文摘

In Japanese quail, testosterone (T) increases the Nissl staining density in the medial preoptic nucleus (POM) in relation to the differential activation by T of copulatory behavior. The effect of T on protein synthesis was quantified here in 97 discrete brain regions by the in vivo autoradiographic ¹⁴C-leucine (Leu) incorporation method in adult gonadectomized male and female quail that had been treated for 4 weeks with T or left without hormone. T activated male sexual behaviors in males but not females. Overall Leu incorporation was increased by T in five brain regions, many of which contain sex steroid receptors such as the POM, archistriatum and lateral hypothalamus. T decreased Leu incorporation in the medial septum. Leu incorporation was higher in males than females in two nuclei but higher in females in three nuclei including the hypothalamic ventromedial nucleus. Significant interactions between effects of T and sex were seen in 13 nuclei: in most nuclei (n