Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats
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- 作者：Baiocchi ; Leonardo ; Alpini ; Gianfranco ; Glaser ; Shannon ; Angelico ; Mario ; Alvaro ; Domenico ; et. al.
- 关键词：Bile acids ; Bicarbonate ; Bile flow ; Adenosine 3&prime ; 5&prime ; -monophosphate ; Hepatocytes ; Intrahepatic biliary epithelium ; Biliary lipid secretion ; Multidrug resistance 2 P-glycoprotein ; ABAT ; Na+-dependent bile acid transporter ; BDI ; bile d
- 刊名：Journal of Hepatology
- 出版年：2003
- 出版时间：February, 2003
- 年：2003
- 卷：38
- 期：2
- 页码：136-147
- 全文大小：405 K
文摘
Background/Aims: Taurohyodeoxycholate (THDCA) and tauroursodeoxycholate (TUDCA) induce more bile flow per molecule excreted compared to endogenous bile acids. The aim of this study is to determine if the hypercholeretic effect of tauroursodeoxycholate or taurohyodeoxycholate in normal and bile duct ligated (BDL) rats is due to increased ductal secretion.