Dorsal raphe nucleus and locus coeruleus neural networks and the elaboration of the sweet-substance-induced antinociception

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• 作者：Renato Kishi ; Renata Bongiovanni ; Tales Rubens de Nadai ; Renato Leonardo Freitas ; Ricardo de Oliveira ; Cé ; lio Marcos dos Reis Ferreira and Norberto Cysne Coimbra
• 关键词：Sweet-substance-induced analgesia ; Tail-flick test ; Dorsal raphe nucleus ; Locus coeruleus ; Pain endogenous inhibitory system
• 刊名：Neuroscience Letters
• 出版年：2006
• 出版时间：27 February 2006
• 年：2006
• 卷：395
• 期：1
• 页码：12-17
• 全文大小：200 K

文摘

In order to investigate the effects of monoaminergic neurons of the dorsal raphe nucleus (DRN) and locus coeruleus (LC) on the elaboration and control of sweet-substance-induced antinociception, male albino Wistar rats weighing 180–200 g received sucrose solution (250 g/L) for 7–14 days as their only source of liquid. After the chronic consumption of sucrose solution, each animal was pretreated with unilateral microinjection of ibotenic acid (1.0 μg/0.2 μL) in the DRN or in the LC. The tail withdrawal latencies of the rats in the tail-flick test were measured immediately before and 7 days after this treatment. The neurochemical lesion of locus coeruleus, but not of DRN neural networks with ibotenic acid, after the chronic intake of sweetened solution, decreased the sweet-substance-induced antinociception. These results indicate the involvement of noradrenaline-containing neurons of the LC in the sucrose-induced antinociception. We also consider the possibility of DRN serotonergic neurons exerting some inhibitory effect on the LC neural networks involved with the elaboration of the sweet-substance-induced antinociception.