PI(3,4,5)P₃ Engagement Restricts Akt Activity to Cellular Membranes

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• 作者：Michael Ebner¹ ; ³ ; Iva Lučić¹ ; ³ ; Thomas A. Leonard¹ ; ² ; ^{thomas.leonard@mfpl.ac.at} ; Ivan Yudushkin¹ ; ² ; ⁴ ; ^{ivan.yudushkin@mfpl.ac.at}
• 关键词：protein kinase B/Akt ; AGC kinases ; allostery ; cellular signaling ; signal transduction ; fluorescence correlation spectroscopy ; fluorescence cross-correlation spectroscopy ; cellular membranes ; phosphatidylinositol-3 ; 4 ; 5-trisphosphate ; protein phosphatases
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：65
• 期：3
• 页码：416-431.e6
• 全文大小：4371 K
• 卷排序：65

文摘

Active Akt is associated exclusively with PIP3- or PI(3,4)P2-containing membranes Allosteric activation by PIP3 and PI(3,4)P2 permits substrate binding PH domain-mediated autoinhibition promotes dephosphorylation of Akt Mutation of autoinhibitory interface drives hyperactivation of Akt in the cytosol