New iron(II) cyclopentadienyl derivative complexes: Synthesis and antitumor activity against human leukemia cancer cells

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• 作者：Andreia Valente^a ; Ana Margarida Santos^a ; Leonor C&ocirc ; rte-Real^a ; M. Paula Robalo^b ; ^c ; Virtudes Moreno^d ; Mercè ; Font-Bardia^e ; ^f ; Teresa Calvet^e ; ^f ; Julia Lorenzo^g ; M. Helena Garcia^a ; ^{lena.garcia@fc.ul.pt" class="auth_mail}
• 关键词：Iron(II) ; Cyclopentadienyl ; Atomic force microscopy (AFM) ; Leukemia cancer cells ; Apoptosis
• 刊名：Journal of Organometallic Chemistry
• 出版年：15 April, 2014
• 年：2014
• 卷：756
• 期：Complete
• 页码：52-60
• 全文大小：1187 K

文摘

A new family of 鈥淔e^II(畏⁵-C₅H₅)鈥?half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P2₁/c and monoclinic P2_1/n space groups, respectively. Studies of interaction of these five new complexes with plasmid pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC₅₀ values revealed excellent antiproliferative activity compared to cisplatin.