- 作者：Irma W.E.M. van Dijk ; MSc&lowast ; ; i.w.vandijk@amc.uva.nl ; Mathilde C. Cardous-Ubbink ; PhD&dagger ; ; Helena J.H. van der Pal ; MD ; PhD&dagger ; ; &Dagger ; ; Richard C. Heinen ; MSc&Dagger ; ; Flora E. van Leeuwen ; PhD§ ; ; Foppe Oldenburger ; MD&lowast ; ; Rob M. van Os ; MSc&lowast ; ; Cé ; cile M. Ronckers ; PhD¡¬ ; Antoinette Y.N. Schouten&ndash ; van Meeteren ; MD ; PhD&Dagger ; ; Huib N. Caron ; MD ; PhD&dagger ; ; &Dagger ; ; Caro C.E. Koning ; MD ; PhD&lowast ; ; Leontien C.M. Kremer ; MD ; PhD&dagger ; ; &Dagger ;
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2013
- 出版时间：1 March, 2013
- 年：2013
- 卷：85
- 期：3
- 页码：768-775
- 全文大小：622 K
class=""h4"">Purpose
To evaluate the prevalence and severity of clinical adverse events (AEs) and treatment-related risk factors in childhood cancer survivors treated with cranial radiation therapy (CRT), with the aim of assessing dose-effect relationships.class=""h4"">Methods and Materials
The retrospective study cohort consisted of 1362 Dutch childhood cancer survivors, of whom 285 were treated with CRT delivered as brain irradiation (BI), as part of craniospinal irradiation (CSI), and as total body irradiation (TBI). Individual CRT doses were converted into the equivalent dose in 2-Gy fractions (EQD2). Survivors had received their diagnoses between 1966 and 1996 and survived at least 5 years after diagnosis. A complete inventory of Common Terminology Criteria for Adverse Events grade 3.0 AEs was available from our hospital-based late-effect follow-up program. We used multivariable logistic and Cox regression analyses to examine the EQD2 in relation to the prevalence and severity of AEs, correcting for sex, age at diagnosis, follow-up time, and the treatment-related risk factors surgery and chemotherapy.
class=""h4"">Results
There was a high prevalence of AEs in the CRT group; over 80 % of survivors had more than 1 AE, and almost half had at least 5 AEs, both representing significant increases in number of AEs compared with survivors not treated with CRT. Additionally, the proportion of severe, life-threatening, or disabling AEs was significantly higher in the CRT group. The most frequent AEs were alopecia and cognitive, endocrine, metabolic, and neurologic events. Using the EQD2, we found significant dose-effect relationships for these and other AEs.
class=""h4"">Conclusion
Our results confirm that CRT increases the prevalence and severity of AEs in childhood cancer survivors. Furthermore, analyzing dose-effect relationships with the cumulative EQD2 instead of total physical dose connects the knowledge from radiation therapy and radiobiology with the clinical experience.