Abnormal nociceptive processing occurs centrally and not peripherally in pain-free Parkinson disease patients: A study with laser-evoked potentials

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• 作者：Sandro Zambito-Marsala^a ; ¹ ; Roberto Erro^b ; ^c ; ¹ ; Ruggero Bacchin^b ; Annalisa Fornasier^a ; Federico Fabris^a ; Cecilia Lo Cascio^a ; Franco Ferracci^a ; Francesca Morgante^d ; Michele Tinazzi^b ; ^{michele.tinazzi@univr.it}
• 关键词：Parkinson disease ; Pain ; Nd ; YAP ; Laser evoked potentials ; Somatosensory system ; Nociception ; Hyperalgesia
• 刊名：Parkinsonism & Related Disorders
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：34
• 期：Complete
• 页码：43-48
• 全文大小：447 K
• 卷排序：34

文摘

Pain is a common symptoms in PD that is often unrelated to the motor disturbances. We observed a significantly reduced N2/P2 LEPs component on both sides, while the N1/P1 component was normal. PD patients had higher laser pain rating than controls, indicative of hyperalgesia. An imbalance between the medial and lateral pain system might explain the genesis of central pain and hyperalgesic phenomena.