Early atherosclerosis aggravates renal microvascular loss and fibrosis in swine renal artery stenosis
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- 作者：Dong Sun ; MD ; PhDa ; b ; Alfonso Eirin ; MDa ; Behzad Ebrahimi ; PhDa ; Stephen C. Textor ; MDa ; Amir Lerman ; MDc ; Lilach O. Lerman ; MD ; PhDa ; c ; lerman.lilach@mayo.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Atherosclerosis ; fibrosis ; micro vascular injury ; renal artery stenosis
- 刊名：Journal of the American Society of Hypertension
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：10
- 期：4
- 页码：325-335
- 全文大小：3137 K
文摘
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Renal artery stenosis (RAS) and atherosclerotic RAS (ARAS) induce similar hypertension and stenotic-kidney dysfunction.
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Swine ARAS magnifies loss of stenotic-kidney cortical microvessels.
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Cortical hypoxia and fibrosis do not correlate with micro vascular loss in RAS.
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In swine, ARAS determinants additional to RAS alone contribute to cortical injury.