Inflammation and autoimmunity reside in the intestinal mucosa, years prior to the onset of detectable joint inflammation.
RA and CD share clinical, epidemiological, serologic, environmental, genetic, dysbiotic and gut permeability manifestations.
The intestine have all the necessary tools to produce neo-epitopes, initiating autoimmunity and autoantibody generation in RA.
Exploring the intestinal routs of RA can lead to intestinal-targeted strategies to prevent, early diagnose or treat RA.