Rheumatoid arthritis-celiac disease relationship: Joints get that gut feeling
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- 作者：Aaron Lernera ; aaronlerner1948@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Torsten Matthiasb ; matthias@aesku.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：RA ; rheumatoid arthritis ; CD ; celiac disease ; RF ; rheumatoid factor ; tTg ; tisue transglutaminase ; anti-CCP ; anticyclic citrullinated protein ; ACPAs ; antibodies to citrullinated protein antigens ; PAD ; peptidylarginine deiminase
- 刊名：Autoimmunity Reviews
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：14
- 期：11
- 页码：1038-1047
- 全文大小：967 K
文摘
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Inflammation and autoimmunity reside in the intestinal mucosa, years prior to the onset of detectable joint inflammation.
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RA and CD share clinical, epidemiological, serologic, environmental, genetic, dysbiotic and gut permeability manifestations.
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The intestine have all the necessary tools to produce neo-epitopes, initiating autoimmunity and autoantibody generation in RA.
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Exploring the intestinal routs of RA can lead to intestinal-targeted strategies to prevent, early diagnose or treat RA.