CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
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- 作者：Matous Hrdinka1 ; 4 ; Berthe Katrine Fiil1 ; 4 ; Mattia Zucca1 ; Derek Leske1 ; Katrin Bagola1 ; Monica Yabal2 ; Paul R. Elliott3 ; Rune Busk Damgaard1 ; 5 ; David Komander3 ; Philipp J. Jost2 ; Mads Gyrd-Hansen1 ; mads.gyrd-hansen@ludwig.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：29 March 2016
- 年：2016
- 卷：14
- 期：12
- 页码：2846-2858
- 全文大小：3705 K
文摘
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CYLD associates with LUBAC via HOIP and limits signaling by NOD2
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RIPK2 ubiquitination is regulated by CYLD and OTULIN
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CYLD trims Lys63 and Met1 linkages conjugated to RIPK2
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Productive NOD2 signaling requires Lys63 and Met1 linkages