Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs

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• 作者：Leslie N. Aldrich ; Sydney L. Stoops ; Brenda C. Crews ; Lawrence J. Marnett ; Craig W. Lindsley
• 关键词：Tambjamine ; Cancer ; Total synthesis
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2010
• 出版时间：1 September 2010
• 年：2010
• 卷：20
• 期：17
• 页码：5207-5211
• 全文大小：718 K

文摘

Herein we disclose the first total synthesis of tambjamine K and a library of unnatural analogs. Unnatural analogs were shown to be more potent in viability, proliferation, and invasion assays than the natural product in multiple cancer cell lines, with minimal to no cytotoxicity on non-transformed cell lines.