Climbing the Scaffolds of Parkinson's Disease Pathogenesis

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• 作者：Brian Spencer ; Leslie Crews ; Eliezer Masliah
• 刊名：Neuron
• 出版年：2007
• 出版时间：15 February 2007
• 年：2007
• 卷：53
• 期：4
• 页码：469-470
• 全文大小：114 K

文摘

Several neurodegenerative disorders, including Parkinson's and Alzheimer's diseases, are characterized neuropathologically by accumulation of misfolded proteins such as α-synuclein that disrupts scaffold molecules in the caveolae. A new study by Ihara et al. in this issue of Neuron shows that a novel scaffold protein, Sept4, may be an important player in modulating the pathological alterations of α-synuclein in models of Parkinson's disease, suggesting that gene therapies targeting scaffold proteins might be effective in the treatment of neurodegenerative disorders.