Tryptophan via serotonin/kynurenine pathways abnormalities in a large cohort of aggressive inmates: markers for aggression
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- 作者：Stefano Comaia ; b ; Antonella Bertazzoc ; Jeanne Vachond ; Marc Daigled ; e ; Jean Toupind ; f ; Gilles Cô ; té ; d ; e ; Gustavo Tureckig ; Gabriella Gobbia ; gabriella.gobbi@mcgill.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Trp ; Tryptophan ; 5-HTP ; 5-hydroxytryptophan ; 5-HT ; serotonin ; Kyn ; kynurenine ; BBB ; blood&ndash ; brain barrier ; TDO ; tryptophan 2 ; 3-dioxygenase ; IDO ; indoleamine 2 ; 3-dioxygenase ; MacCVI ; MacArthur Community Violence Instrument ; LSARS ; Lethality of Suicide Attempt Rating Scale ; SCID-I ; Structured Clinical Interview for DSM-IV Axis-I Disorders ; SCID-II ; Structured Clinical Interview for DSM-IV Axis-II Disorders ; GAF ; global assessment of functioning ; ASPD ; antisocial personality disorder ; BIS ; Barr
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：3 October 2016
- 年：2016
- 卷：70
- 期：Complete
- 页码：8-16
- 全文大小：738 K
文摘
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Altered metabolism of tryptophan via serotonin and kynurenine in aggressive inmates;
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Aggressive inmates display increased serum 5-HT/Trp ratio;
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The serum Kyn/Trp ratio is correlated to the number of severe aggressive acts;
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Only a combination of biological and psychopathological markers predicts aggression.