Taenia crassiceps infection abrogates experimental autoimmune encephalomyelitis

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• 作者：Jos&#xe9 ; L. Reyes^a ; Arlett F. Espinoza-Jim&#xe9 ; nez^a ; Marisol I. Gonz&#xe1 ; lez^a ; Leticia Verdin^a ; Luis I. Terrazas ; ^a ; ^{literrazas@campus.iztacala.unam.mx}
• 关键词：Taenia crassiceps ; Alternatively activated macrophages ; T helper 2 cells ; Foxp3 T regulatory cells ; EAE ; IL-10
• 刊名：Cellular Immunology
• 出版年：2011
• 出版时间：2011
• 年：2011
• 卷：267
• 期：2
• 页码：77-87
• 全文大小：1493 K

文摘

Helminth infections induce strong immunoregulation that can modulate subsequent pathogenic challenges. Taenia crassiceps causes a chronic infection that induces a Th2-biased response and modulates the host cellular immune response, including reduced lymphoproliferation in response to mitogens, impaired antigen presentation and the recruitment of suppressive alternatively activated macrophages (AAMФ). In this study, we aimed to evaluate the ability of T. crassiceps to reduce the severity of experimental autoimmune encephalomyelitis (EAE). Only 50 % of T. crassiceps-infected mice displayed EAE symptoms, which were significantly less severe than uninfected mice. This effect was associated with both decreased MOG-specific splenocyte proliferation and IL-17 production and limited leukocyte infiltration into the spinal cord. Infection with T. crassiceps induced an anti-inflammatory cytokine microenvironment, including decreased TNF-α production and high MOG-specific production of IL-4 and IL-10. While the mRNA expression of TNF-α and iNOS was lower in the brain of T. crassiceps-infected mice with EAE, markers for AAMФ were highly expressed. Furthermore, in these mice, there was reduced entry of CD3⁺Foxp3⁻ cells into the brain. The T. crassiceps-induced immune regulation decreased EAE severity by dampening T cell activation, proliferation and migration to the CNS.