Low-dose human chorionic gonadotropin versus estradiol/progesterone luteal phase support in gonadotropin-releasing hormone agonist–triggered assisted reproductive technique cycles: understanding a new approach

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• 作者：Juan A. Garcia-Velasco ; Leticia Motta ; Ana L&#xf3 ; pez ; Mercedes Mayoral ; Maria Cerrillo ; Alberto Pacheco
• 关键词：hCG ; estradiol ; progesterone ; luteal phase ; GnRH agonist
• 刊名：Fertility and Sterility
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：94
• 期：7
• 页码：2820-2823
• 全文大小：81 K

文摘

It remains unclear how GnRH agonist (GnRHa) triggering affects the luteal phase, so we investigated the luteal phase after GnRHa triggering, supported with conventional E₂/P with or without low-dose hCG. E₂/P support, compared with low-dose hCG, induced a shorter luteal phase (11.2 ± 1.1 vs. 15.0 ± 1.6 days) and fewer subjective complaints (0 vs. 42 % ), whereas hCG caused more free fluid accumulation and enlarged ovaries than E₂/P alone. Steroids and low-dose hCG differentially affected corpus luteum function, ovarian size, free fluid accumulation, and patient comfort.