Rostral anterior cingulate cortex theta current density and response to antidepressants and placebo in major depression

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• 作者：Alex ; er S. Korb ; Aimee M. Hunter ; Ian A. Cook ; Andrew F. Leuchter
• 关键词：Depression ; EEG ; LORETA ; Placebo ; Anterior cingulate
• 刊名：Clinical Neurophysiology
• 出版年：2009
• 出版时间：July 2009
• 年：2009
• 卷：120
• 期：7
• 页码：1313-1319
• 全文大小：1188 K

文摘

Objective

To assess whether pretreatment theta current density in the rostral anterior cingulate (rACC) and medial orbitofrontal cortex (mOFC) differentiates responders from non-responders to antidepressant medication or placebo in a double-blinded study.

Methods

Pretreatment EEGs were collected from 72 subjects with Major Depressive Disorder (MDD) who participated in one of three placebo-controlled trials. Subjects were randomized to receive treatment with fluoxetine, venlafaxine, or placebo. Low-resolution brain electromagnetic tomography (LORETA) was used to assess theta current density in the rACC and mOFC.

Results

Medication responders showed elevated rACC and mOFC theta current density compared to medication non-responders (rACC: p = 0.042; mOFC: p = 0.039). There was no significant difference in either brain region between placebo responders and placebo non-responders.

Conclusions

Theta current density in the rACC and mOFC may be useful as a biomarker for prediction of response to antidepressant medication.

Significance

This is the first double-blinded treatment study to examine pretreatment rACC and mOFC theta current density in relation to antidepressant response and placebo response. Results support the potential clinical utility of this approach for predicting clinical outcome to antidepressant treatments in MDD.