Heart regeneration

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• 作者：Kaja Breckwoldt^a ; ^b ; Florian Weinberger^c ; Thomas Eschenhagen^a ; ^b ; ^{t.eschenhagen@uke.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：AAV ; adeno-associated virus ; CM ; cardiomyocyte ; EHT ; engineered heart tissue ; ESC ; embryonic stem cell ; hEHT ; human engineered heart tissue ; hESC ; human embryonic stem cell ; hiPSC ; human induced pluripotent stem cell ; HLA ; human leucocyte antigen ; hNT-ESC ; human nuclear transfer-mediated ESC ; hPGSC ; human parthenogenetic stem cell ; hPSC ; human pluripotent stem cell ; iPSC ; induced pluripotent stem cell ; LVAD ; ventricular assist devices ; PSC-CM ; pluripotent stem cell-derived cardiomyocyte ; SCNT ; s
• 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：1863
• 期：7
• 页码：1749-1759
• 全文大小：752 K

文摘

Regenerating an injured heart holds great promise for millions of patients suffering from heart diseases. Since the human heart has very limited regenerative capacity, this is a challenging task. Numerous strategies aiming to improve heart function have been developed. In this review we focus on approaches intending to replace damaged heart muscle by new cardiomyocytes. Different strategies for the production of cardiomyocytes from human embryonic stem cells or human induced pluripotent stem cells, by direct reprogramming and induction of cardiomyocyte proliferation are discussed regarding their therapeutic potential and respective advantages and disadvantages. Furthermore, different methods for the transplantation of pluripotent stem cell-derived cardiomyocytes are described and their clinical perspectives are discussed. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.