Identification of a novel HLA-A allele, HLA-A*01:195, in a UAE national

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• 作者：Wael Abdrabou^a ; ¹ ; Ini-Isabé ; e Witzel^a ; ¹ ; Agnieszka Paduch^b ; Guan Tay^c ; Habiba Alsafar^a ; ^d ; ^{Habiba.Alsafar@kustar.ac.ae" class="auth_mail" title="E-mail the corresponding author}
• 关键词：GSSP ; group specific sequencing primer ; HLA ; human leukocyte antigen ; IMGT ; immunogenetics project ; Ile ; isoleucine ; MHC ; major histocompatibility complex ; PCR ; polymerase chain reaction ; SBT ; sequence-based typing ; UAE ; United Arab Emirates ; Val ; valine ; WHO ; World Health Organization
• 刊名：Human Immunology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：77
• 期：7
• 页码：605-608
• 全文大小：606 K

文摘

A novel human leucocyte antigen (HLA)-A allele, HLA-A*01:195, was identified by sequence-based typing (SBT) in a UAE national subject. The novel allele is identical to its closest known allele, HLA-A*01:01:01:01, in exon 2, 3 and 4, except for a single nucleotide mutation of A to G at position 442 in exon 3 (codon 124 in the α2 domain of the α chain of the mature protein). This A to G mutation results in an amino acid change of isoleucine #124 to valine.