Mitochondria: An intriguing target for killing tumour-initiating cells
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- 作者：Bing Yana ; bing.yan@griffithuni.edu.au" class="auth_mail" title="E-mail the corresponding author ; Lanfeng Donga ; Jiri Neuzila ; b ; j.neuzil@griffith.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：AML ; acute myeloid leukaemia ; BH3 ; Bcl-2 homology-3 ; CII ; complex II ; CSCs ; cancer stem cells ; MitoVES ; mitochondrially targeted vitamin E succinate ; ROS ; reactive oxygen species ; SCs ; stem cells ; TICs ; tumour-initiating cells ; α-TOS ; α-tocopheryl succinate ; TPP+ ; ; triphenylphosphonium
- 刊名：Mitochondrion
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：26
- 期：Complete
- 页码：86-93
- 全文大小：583 K
文摘
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Elimination of tumour-initiating cells (TICs) is essential for cancer therapy.
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Specific properties of mitochondria make this organelle a promising target for anti-TIC agents.
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Mitocans, a class of anti-cancer drugs acting by way of mitochondrial ‘destabilisation’, include agents that show a considerable potential in killing TICs.