Sphingosine 1-phospate differentially modulates maturation and function of human Langerhans-like cells
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- 作者：Stephanie Bock ; Anja Pfalzgraff ; Gü ; nther Weindl ; Guenther.Weindl@fu-berlin.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：AML ; acute myeloid leukaemia ; APC ; antigen presenting cell ; CMC ; cytokine maturation cocktail ; DC ; dendritic cell ; GPCR ; G protein-coupled receptor ; LC ; Langerhans cell ; MoDC ; monocyte-derived DC ; MoLC ; monocyte-derived LC ; PRR ; pattern recognition receptor ; S1P ; sphingosine 1-phosphate ; S1PR ; S1P receptor ; TLR ; Toll-like receptor
- 刊名：Journal of Dermatological Science
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：82
- 期：1
- 页码：9-17
- 全文大小：1487 K
文摘
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Human LCs express a distinct S1P receptor profile.
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Activation of S1P receptors does not induce complete maturation of human LCs but reduces cytokine release in mature LCs.
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S1P is a chemoattractant for LCs and reduces migration of immature and mature MUTZ-LCs but not MoLCs.
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Exogenous and endogenous S1P signalling is dispensable for LC endocytosis.