Regulation of the tumor marker Fascin by the viral oncoprotein Tax of human T-cell leukemia virus type 1 (HTLV-1) depends on promoter activation and on a promoter-independent mechanism
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- 作者：Caroline F. Mohra ; caroline.mohr@viro.med.uni-erlangen.de" class="auth_mail" title="E-mail the corresponding author ; Christine Grossa ; christine.gross@viro.med.uni-erlangen.de" class="auth_mail" title="E-mail the corresponding author ; Matthias Brosb ; mbros@uni-mainz.de" class="auth_mail" title="E-mail the corresponding author ; Angelika B. Reske-Kunzb ; A.Reske-Kunz@uni-mainz.de" class="auth_mail" title="E-mail the corresponding author ; Brigitte Biesingera ; Brigitte.Biesinger-Zwosta@viro.med.uni-erlangen.de" class="auth_mail" title="E-mail the corresponding author ; Andrea K. Thoma-Kressa ; aakress@viro.med.uni-erlangen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tumor virus ; HTLV-1 ; Oncogene ; Tax ; ATL ; Fascin ; Transcription regulation ; Promoter ; NF鈥恔appa B (NF鈥怟B) ; PP2
- 刊名：Virology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：485
- 期：Complete
- 页码：481-491
- 全文大小：2169 K
文摘
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The viral oncoprotein Tax induces the invasion marker Fascin by at least three signals.
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Tax activates the Fascin promoter phF1.6 dependent on NF-魏B and on a Tax-responsive region.
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Tax induces Fascin by a promoter-independent step sensitive to the Src family kinase inhibitor PP2.
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The invasion marker Fascin is a novel target of PP2, an inhibitor of metastasis.