Lipid mediators foster the differentiation of T follicular helper cells

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• 作者：Tomonori Nagaya^a ; ^b ; ¹ ; Koji Kawata^a ; ¹ ; Ryuta Kamekura^a ; ^b ; Sumito Jitsukawa^a ; ^b ; Terufumi Kubo^c ; Motonari Kamei^a ; Noriko Ogasawara^b ; Ken-ichi Takano^b ; Tetsuo Himi^b ; Shingo Ichimiya^a ; ^{ichimiya@sapmed.ac.jp}
• 关键词：Tfh cells ; T follicular helper cells ; LXA4 ; lipoxin A4 ; LTB4 ; leukotriene B4 ; FPR2 ; formyl peptide receptor 2
• 刊名：Immunology Letters
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：181
• 期：Complete
• 页码：51-57
• 全文大小：1843 K
• 卷排序：181

文摘

Naïve T cells have certain expression of the lipoxin 4 (LXA4) receptor FPR2 at mRNA and protein level. LXA4 as well as leukotriene B4 (LTB4) facilitated the differentiation of naïve CD4+ T cells into T follicular helper cells. Direct activation of FPR2 by LXA4 enhances Tfh cell differentiation.