Eicosanoid receptors: Targets for the treatment of disrupted intestinal epithelial homeostasis

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• 作者：Juan J. Moreno ^{jjmoreno@ub.edu}
• 关键词：Prostaglandin E2 (PubChem CID ; 5280360) ; Leukotriene B4 (PubChem CID ; 5280492) ; 12-Hydroxyheptadecatrenoic acid (PubChem CID ; 5283141) ; Leukotriene D4 (PubChem CID ; 5280878) ; Lipoxin A4 (PubChem CID ; 5280914) ; Carbacyclin (PubChem CID ; 6436393) ; Butaprost acid (PubChem CID ; 25886893) ; Sulprostone (PubChem CID ; 5312153) ; U75302 (PubChem CID ; 6449854) ; Tomelukast (PubChem CID ; 3969)
• 刊名：European Journal of Pharmacology
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：796
• 期：Complete
• 页码：7-19
• 全文大小：1100 K
• 卷排序：796

文摘

The importance of cyclooxygenase and lipoxygenase pathways and the consequent eicosanoid synthesis in the physiology and pathophysiology of the intestinal epithelium is currently being established. Each eicosanoid (prostanoid, leukotriene, hydroxyeicosatetraenoic acid) preferentially recognizes one or more receptors coupled to one or more signal-transduction processes. This overview focuses on the role of eicosanoid receptors in the maintenance of intestinal epithelium physiology through the control of proliferation/differentiation/apoptosis processes. Furthermore, it is reported that the role of these receptors on the regulation of the barrier function of the intestinal epithelium have arisen through the regulation of absorption/secretion processes, tight-junction state and the control of the intestinal immune response. Also, this review considers the implication of AA cascade in the disruption of epithelial homeostasis during inflammatory bowel diseases and colorectal cancer as well as the therapeutic values and potential of the eicosanoid receptors as novel targets for the treatments of the pathologies above mentioned.