Dry eye (DE) exams should include an evaluation of neuropathic ocular pain (NOP).
DE patients with more chronic pain syndromes (high CPS group) reported NOP.
The high CPS group reported worse DE, depression, quality of life, and ocular and non-ocular pain.
NOP may share causal genetic factors with other overlapping chronic pain conditions.
Multidisciplinary chronic pain treatment may also benefit DE patients with NOP.