Dry Eye Profiles in Patients with a Positive Elevated Surface Matrix Metalloproteinase 9 Point-of-Care Test Versus Negative Patients

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• 作者：Nicole L. Lanza ; MEd¹ ; ² ; Allison L. McClellan ; OD¹ ; Hatim Batawi ; MD¹ ; ² ; Elizabeth R. Felix ; PhD¹ ; ³ ; Konstantinos D. Sarantopoulos ; MD ; PhD¹ ; ⁴ ; Roy C. Levitt ; MD¹ ; ⁴ ; ⁵ ; ⁶ ; Anat Galor ; MD ; MSPH¹ ; ² ; ^{agalor@med.miami.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：dry eye ; InflammaDry ; matrix metalloproteinase-9
• 刊名：The Ocular Surface
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：14
• 期：2
• 页码：216-223
• 全文大小：191 K

文摘

To compare dry eye (DE) symptoms and signs in subjects who tested positive versus those who tested negative for ocular surface matrix metalloproteinase 9 (ass="boldFont">MMP-9) using the InflammaDry point-of-care test (RPS, Sarasota, FL).

absSec_2">Methods

abspara0015">In this cross-sectional study, individuals seen in the Miami Veterans Affairs eye clinic with DE symptoms, as evidenced by DE questionnaire 5 (ass="boldFont">DEQ5) ≥6, were given standardized questionnaires to assess DE symptoms and ocular and non-ocular pain complaints. Also, a complete evaluation was conducted to measure ocular surface signs of DE. MMP-9 testing was performed using the InflammaDry once in each eye, per the manufacturer's instructions. The main outcome measure was a comparison of DE symptoms and signs in MMP-9 positive versus negative subjects.

absSec_3">Results

abspara0020">Of 128 subjects, 50 (39%) were positive for MMP-9 for InflammaDry testing in either eye. No statistically significant differences in mental health indices, DE symptoms, or ocular surface signs were seen in subjects based on MMP-9 status.

absSec_4">Conclusion

abspara0025">In our population, there was no difference in the DE profile by both symptoms and signs between those testing positive versus negative for MMP-9 on the ocular surface. This suggests that clinical exam alone cannot predict patients with clinically significant inflammation.