Strain and cocaine-induced differential opioid gene expression may predispose Lewis but not Fischer rats to escalate cocaine self-administration
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- 作者：Marta Valenzaa ; mvalenza@rockefeller.edu" class="auth_mail" title="E-mail the corresponding author ; Roberto Picettia ; b ; Vadim Yuferova ; Eduardo R. Butelmana ; Mary Jeanne Kreeka
- 关键词：Cocaine addiction ; Dynorphin ; Dorsal striatum ; Extended access self-administration ; Kappa opioid receptor ; Nucleus accumbens ; Opioid peptides ; Opioid receptors
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：105
- 期：Complete
- 页码：639-650
- 全文大小：1631 K
文摘
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Lewis, but not Fischer rats, escalate cocaine intake during 14 extended access (18 h) self-administration sessions.
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Cocaine-induced gene expression changes were observed primarily in the dorsal, but not the ventral, part of the striatum.
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Strain differences were observed in basal striatal level of Pomc, Pdyn, Penk, Oprm, Oprk, and Oprd mRNA.
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mRNA level of Pdyn and Oprk, in the Dorsal Striatum correlates with individual cocaine intake selectively in Fischer rats.