Reproductive toxicity of linuron following gestational exposure in rats and underlying mechanisms

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• 作者：Hongwei Ding^a ; Wei Zheng^b ; Hua Han^a ; Xiyin Hu^a ; Binli Hu^a ; Feng Wang^a ; Liyu Su^a ; Hong Li^a ; Yan Li^a ; ^{liyan067321@sina.com}
• 关键词：Linuron ; Testosterone ; Offspring ; Reproductive toxicity ; Developmental toxicity ; Fetus ; Leydig cells
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：266
• 期：Complete
• 页码：49-55
• 全文大小：3462 K
• 卷排序：266

文摘

Linuron-induced developmental toxicity in male offspring gonadal organs was studied. Maternal exposure to linuron hampers male gonadal organ development in fetus. Maternal exposure to linuron harms offspring seminiferous tubules and Leydig cells. Linuron toxicity is due to its direct effect on the production of testosterone.