Prooxidant activity of melatonin promotes fas-induced cell death in human leukemic Jurkat cells
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- 作者：Wö ; lfler ; Albert ; Caluba ; Hans-Christian ; Abuja ; Peter M. ; Dohr ; Gottfried ; Schauenstein ; Konrad ; et. al.
- 关键词：Melatonin ; Reactive oxygen species ; Lymphocyte apoptosis ; Cellular redox regulation ; ROS ; reactive oxygen species ; MEL ; melatonin ; DHR ; dihydrorhodamine ; mAb ; monoclonal antibody ; FCS ; fetal calf serum ; GSH ; glutathione ; BSO ; buthionine-sulfoximine ; EGSH
- 刊名：FEBS Letters
- 出版年：2001
- 出版时间：August 3, 2001
- 年：2001
- 卷：502
- 期：3
- 页码：127-131
- 全文大小：173 K
文摘
The antioxidant activity of melatonin (MEL) has been considered to constitute part of its physiological as well as pharmacological effects. However, as described herein we found a profound prooxidant activity of micro- to millimolar concentrations of MEL in the human leukemic Jurkat cell line. This prooxidant effect was increased in glutathione-depleted cells and counteracted by antioxidants. As a consequence MEL promoted fas-induced cell death. These data therefore indicate that MEL may be a modulator of the cellular redox status, but does not necessarily act as an intracellular antioxidant.