Lgr4 is crucial for skin carcinogenesis by regulating MEK/ERK and Wnt/β-catenin signaling pathways
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- 作者：Peng Xua ; 1 ; Yongyan Danga ; 1 ; Luyang Wanga ; Xia Liua ; Xiaolin Rena ; Jun Gub ; Mingyao Liua ; Xing Daic ; xdai@uci.edu" class="auth_mail" title="E-mail the corresponding author ; Xiyun Yea ; xyye@bio.ecnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lgr4 ; Squamous cell carcinoma ; TPA ; ERK1/2 ; β-Catenin
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 December 2016
- 年：2016
- 卷：383
- 期：2
- 页码：161-170
- 全文大小：3271 K
文摘
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Mice deficient for Lgr4 are resistant to TPA-induced keratinocyte proliferation and onset of papillomas.
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TPA treatment activated MEK1/ERK1/2/AP-1 and Wnt/β-catenin signaling pathways in vitro and in vivo in wild-type but not Lgr4−/− mice.
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We provide evidence that MEK1/ERK1/2 pathway activation lies upstream of Wnt/β-catenin pathway activation during mouse skin tumor formation.