LGR4 acts as a key receptor for R-spondin 2 to promote osteogenesis through Wnt signaling pathway
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- 作者：Chao Zhu1 ; Xin-Feng Zheng1 ; Yue-Hua Yang ; Bo Li ; Yu-Ren Wang ; Sheng-Dan Jiang ; jiangsd@126.com" class="auth_mail" title="E-mail the corresponding author ; Lei-Sheng Jiang ; 2 ; jiangleisheng@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：R-spondin 2 ; LGR4 ; Wnt/β-catenin signaling ; Osteoblast ; Osteoclast
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：28
- 期：8
- 页码：989-1000
- 全文大小：2805 K
文摘
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R-spondin 2 promoted osteogenesis through activating the Wnt/β-catenin signaling pathway.
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LGR4 acted as a pivotal receptor for R-spondin 2 to promote osteogenesis.
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Rspo2 inhibited osteoclastogenesis and this effect of Rspo2 was dependent on osteoblasts.
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Exogenous recombinant R-spondin 2 could rescue the bone loss in OVX mice.