Rourinoside and rouremin, antimalarial constituents from Rourea minor

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• 作者：Zhen-Dan He ; Cui-Ying Ma ; Ghee Teng Tan ; Kongmany Sydara ; Pamela Tamez ; Bounhoong Southavong ; Somsanith Bouamanivong ; D. Doel Soejarto ; John M. Pezzuto ; Harry H.S. Fong and Hong-Jie Zhang
• 关键词：Rourea minor ; Connaraceae ; Rourinoside ; Rouremin ; Antimalarial activity ; 2D NMR
• 刊名：Phytochemistry
• 出版年：2006
• 出版时间：July 2006
• 年：2006
• 卷：67
• 期：13
• 页码：1378-1384
• 全文大小：253 K

文摘

Bioassay-directed fractionation of the antimalarial active CHCl₃ extract of the dried stems of Rourea minor (Gaertn.) Aubl. (Connaraceae) liana led to isolation of two glycosides, rourinoside (1) and rouremin (2), as well as five known compounds, 1-(26-hydroxyhexacosanoyl)-glycerol (3), 1-O-β-d-glucopyranosyl-(2S,3R,4E-8Z)-2-N-(2′-hydroxypalmitoyl)-octadecasphinga-4,8-dienine, 9S,12S,13S-trihydroxy-10E-octadecenoic acid, dihydrovomifoliol-9-β-d-glucopyranoside, and β-sitosterol glucoside. Compounds 1–3 showed weak in vitro activities against Plasmodium falciparum. Their structures and stereochemistry were elucidated by spectroscopic methods and selected enzyme hydrolysis.