Transduction of interleukin-10 through renal artery attenuates vascular neointimal proliferation and infiltration of immune cells in rat renal allograft
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- 作者：Jingxin Xie1 ; Xueyi Li1 ; Dan Meng ; Qiujuan Liang ; Xinhong Wang ; Li Wang ; Rui Wang ; Meng Xiang ; Sifeng Chen ; Chen1216@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：IL-10 ; cytokine interleukin-10 ; HO-1 ; heme oxygenase-1 ; AAV1-IL-10 ; adeno-associated viral vector carrying interleukin-10 gene ; CsA ; cyclosporine ; ATF-6 ; transcription factor-6 ; TNF-α ; tumor necrosis factor-α ; IFN-γ ; interferon-γmonocyte ; MCP-1 ; chemotactic protein-1 ; GM/CSF ; granulocyte macrophage colony stimulating factor ; GRO/KC ; growth-related oncogene
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：176
- 期：Complete
- 页码：105-113
- 全文大小：3409 K
文摘
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Intrarenal IL-10 inhibited kidney allograft rejection.
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Intrarenal IL-10 gene transduction induced prolonged IL-10 increase in kidney allograft but transient serum IL-10 increase.
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Intrarenal IL-10 modulated immune response in kidney allograft.