Bacteremia due to carbapenem-resistant Enterobacteriaceae in neutropenic patients with hematologic malignancies
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- 作者：Michael J. Satlina ; mjs9012@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Nina Cohenf ; cohenn@mskcc.org" class="auth_mail" title="E-mail the corresponding author ; Kevin C. Mab ; kcm9006@nyp.org" class="auth_mail" title="E-mail the corresponding author ; Zivile Gedrimaitef ; gedrimaz@mskcc.org" class="auth_mail" title="E-mail the corresponding author ; Rosemary Soavea ; rsoave@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Gü ; lce Askinc ; gua2004@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Liang Cheng ; chen11@njms.rutgers.edu" class="auth_mail" title="E-mail the corresponding author ; Barry N. Kreiswirthg ; kreiswba@njms.rutgers.edu" class="auth_mail" title="E-mail the corresponding author ; Thomas J. Walsha ; d ; e ; thw2003@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Susan K. Seof ; seos@mskcc.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Carbapenem-resistant Enterobacteriaceae ; Neutropenic patients ; Hematologic malignancies ; Bacteremia ; Prevalence ; Risk factors ; Outcomes
- 刊名：Journal of Infection
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：73
- 期：4
- 页码：336-345
- 全文大小：601 K
文摘
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CRE caused 2.2% of all BSIs and 4.7% of Gram-negative BSIs in neutropenic patients.
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Multiple antibiotics, steroids and a prior CRE culture were CRE BSI risk factors.
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Patients with CRE BSI had a 2–3-day delay until receipt of CRE-active therapy.
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The CRE BSI-related mortality rate was 51%, with a median of 4 days until death.
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New strategies are needed to mitigate this threat in this vulnerable population.