Generation of Biostable L-aptamers against Achiral Targets by Chiral Inversion of Existing D-aptamers

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• 作者：Huapei Chen^a ; Sitao Xie^a ; Hao Liang^a ; Cuichen Wu^b ; Liang Cui^a ; ^{cuiliang@hnu.edu.cn} ; Shuang-Yan Huan^a ; ; Xiaobing Zhang^a ; ^{xbzhang@hnu.edu.cn}
• 关键词：Aptamers ; Biostability ; Malachite green ; Ethanolamine ; Mirror image
• 刊名：Talanta
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：164
• 期：Complete
• 页码：662-667
• 全文大小：645 K
• 卷排序：164

文摘

L-aptamers shows robust biostability to realize detection in complex samples. The straightforward transformation of the mirror structure is simple in design. RNA and DNA aptamers are both suitable for this strategy, which shows generality.