Glycoholics Anonymous: Cancer Sobers Up with mTORC1

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• 作者：Vivian Fu¹ ; Toshiro Moroishi¹ ; Kun-Liang Guan¹ ; ^{kuguan@ucsd.edu" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Cancer Cell
• 出版年：2016
• 出版时间：11 April 2016
• 年：2016
• 卷：29
• 期：4
• 页码：432-434
• 全文大小：2758 K

文摘

In this issue of Cancer Cell, Pusapati et al. (2016) reveal that mTORC1 orchestrates the metabolic reprogramming of cancer cells in response to glycolytic inhibitors, bypassing glycolysis by increasing glutamine uptake and pentose phosphate flux to generate energy and biomass.