Activity-based and fraction-guided analysis of Phyllanthus urinaria identifies loliolide as a potent inhibitor of hepatitis C virus entry
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- 作者：Chueh-Yao Chunga ; Ching-Hsuan Liub ; Thierry Burnoufc ; Guey-Horng Wangd ; Shun-Pang Change ; Alagie Jasseyb ; f ; Chen-Jei Taig ; h ; Cheng-Jeng Taii ; j ; Ching-Jang Huangk ; Christopher D. Richardsonl ; m ; Ming-Hong Yena ; Chun-Ching Lina ; e ; aalin@kmu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Liang-Tzung Linb ; f ; ltlin@tmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatitis C ; Antiviral ; Natural product ; Phyllanthus urinaria ; Loliolide ; Viral entry
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：130
- 期：Complete
- 页码：58-68
- 全文大小：1885 K
文摘
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Multiple fractions from Phyllanthus urinaria exhibit anti-HCV activity.
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Loliolide isolated from fraction 13 is an efficient inhibitor of HCV viral entry.
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Loliolide inactivates HCV virion and blocks viral attachment and entry/fusion.
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Loliolide merits further development as an entry inhibitor to HCV infection.
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P. urinaria may be a potent source for the discovery of anti-HCV agents.