Mutation spectra of RAS gene family in colorectal cancer
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- 作者：Yu-Yao Chang ; M.D.a ; b ; c ; Pei-Ching Lin ; M.D.d ; Hung-Hsin Lin ; M.D.a ; b ; Jen-Kou Lin ; M.D. ; Ph.D.a ; b ; Wei-Shone Chen ; M.D. ; Ph.D.a ; b ; Jeng-Kai Jiang ; M.D. ; Ph.D.a ; b ; Shung-Haur Yang ; M.D. ; Ph.D.a ; b ; Wen-Yih Liang ; M.D. ; Ph.D.e ; Shih-Ching Chang ; M.D. ; Ph.D.a ; b ; changsc@vghtpe.gov.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Colorectal cancer ; KRAS ; NRAS ; HRAS ; Survival
- 刊名：The American Journal of Surgery
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：212
- 期：3
- 页码：537-544.e3
- 全文大小：886 K
文摘
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Of the 1,519 colorectal cancer patients, 602 (39.6%), 66 (4.3%), and 26 (1.7%) were found to have KRAS, NRAS, and HRAS mutations, respectively.
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The KRAS mutation was associated with fewer left-sided tumors, fewer poor differentiated tumors, more mucin component, and less lymphovascular invasion.
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Patients with the NRAS mutation, but not the KRAS or HRAS mutation, had an insignificantly worse outcome.