JAK and STAT members of yellow catfish Pelteobagrus fulvidraco and their roles in leptin affecting lipid metabolism
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- 作者：Kun Wu ; Xiao-Ying Tan ; 1 ; txy7933@163.com" class="auth_mail" title="E-mail the corresponding author ; txy7933@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; xt86@cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Yi-Huan Xu ; Qi-Liang Chen ; Ya-Xiong Pan
- 关键词：ACC ; acetyl-CoA carboxylase ; B2M ; beta-2-microglobulin ; CPT I ; carnitine palmitoyl transferase I ; FAS ; fatty acid synthase ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; HPRT ; hypoxanthine-guanine phosphoribosyl transferase ; HSL ; hormone-sensitive lipase ; JAK ; janus kinase ; MS-222 ; tricaine methanesulfonate ; RPL7 ; ribosomal protein L7 ; STAT ; signal transducer and activator of transcription ; TBP ; TATA-box-binding protein ; TG ; triglyceride ; TUBA ; tubulin alpha chain ; UBCE ; ubiquitin-conjugating
- 刊名：General and Comparative Endocrinology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：226
- 期：Complete
- 页码：14-26
- 全文大小：9962 K
文摘
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Full-length cDNA sequences of five JAKs and seven STAT members were obtained from yellow catfish.
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All of these members were widely expressed across the eleven tissues but at the variable levels.
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Leptin changed TG content and mRNA expression of several JAKs and STATs members, and genes involved in lipid metabolism.
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JAK2a/b–STAT3 pathway exerts main actions in leptin influencing lipid metabolism.