A LC-MS/MS method for the determination of stachyose in rat plasma and its application to a pharmacokinetic study
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- 作者：Yang Zhoua ; b ; De-sheng Xua ; b ; xudes1953@126.com" class="auth_mail" title="E-mail the corresponding author ; Li Liua ; b ; liuli2750@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Fu-rong Qiua ; b ; Jiong-liang Chenb ; Guang-lin Xua
- 关键词：HPLC ; high performance liquid chromatography ; HPLC-RID ; high performance liquid chromatography with refractive index detector ; HPLC-ELSD ; high performance liquid chromatography with evaporative light scattering detector ; LC&ndash ; MS ; liquid chromatograph-mass spectrometer ; LC&ndash ; MS/MS ; liquid chromatography-tandem mass spetrometry ; IS ; internal standard ; RFOs ; raffinose family oligosaccharides ; RGOS ; Rehmannia glutinosa oligosaccharides ; COPD ; chronic obstructive pulmonary disease ; MRM ; multi
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：10 May 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：24-30
- 全文大小：1635 K
文摘
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This is the first report for the determination of stachyose in rat plasma.
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A sensitive, simple and rapid analytical method based on LC–MS/MS has been established and validated for the determination of stachyose in rat plasma.
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The validated method was successfully applied to a pharmacokinetic study in rats.