A new side-polished fiber optic SPR sensor was fabricated for rapid virus detection.
The SPR sensor limit of detection for avian influenza H6 was 5.14 × 105 EID50/0.1 mL.
AC ELISA detected 2.1 × 106 and PCR 2.6 × 104 EID50/0.1 mL.
The sensor detection of 10 min and compact size is suitable for rapid diagnosis.