New antioxidant and antiglycation active triterpenoid saponins from the root bark of Aralia taibaiensis

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• 作者：Linlin  ; Bi^a ;   ; ^b ; Xiangrong  ; Tian^b ;   ; ^c ; Fang  ; Dou^b ; Liangjian  ; Hong^b ; Haifeng  ; Tang^b ;   ; ^{tanghaifeng71@163.com} ; Siwang  ; Wang^a ;   ; ^{wangsiw@fmmu.edu.cn}
• 关键词：Aralia taibaiensis ; Triterpenoid saponin ; Antioxidant ; Antiglycation ; Diabetes mellitus
• 刊名：Fitoterapia
• 出版年：2012
• 出版时间：January 2012
• 年：2012
• 卷：83
• 期：1
• 页码：234-240
• 全文大小：293 K

文摘

Four new oleanane type triterpenoid saponins (1?b xmlns="""">4) and a known saponin (5) were isolated from the root bark of Aralia taibaiensis Z.Z. Wang et H.C. Zheng. The structures of the four new compounds were elucidated as 3-O-{¦Â-d-glucopyranosyl-(1 ?2)-[¦Â-d-glucopyranosyl-(1 ?3)]-¦Â-d-glucurono-pyranosyl}-olean-11,13(18)-diene-28-oic acid 28-O-¦Â-d-glucopyranosyl ester (1), 3-O-{¦Â-d-gluco-pyranosyl-(1 ?3)-[¦Á-l-arabinofuranosyl-(1 ?4)]-¦Â-d-glucuronopyranosyl}-olean-11,13(18)-diene-28-oic acid 28-O-¦Â-D-glucopyranosyl ester (2), 3-O-{¦Â-d-glucopyranosyl-(1 ?2)-[¦Á-l-arabinofuranosyl-(1 ?4)]-¦Â-d-glucuronopyranosyl}-oleanolic acid 28-O-¦Â-D-glucopyranosyl ester (3) and 3-O-{¦Â-d-glucopyranosyl-(1 ?2)-[¦Â-d-glucopyranosyl-(1 ?3)]-¦Â-d-glucuronopyranosyl}-oleanolic acid 28-O-¦Â-d-glucopyranosyl ester (4), on the basis of extensive spectral analysis and chemical evidence. Compounds 1?b xmlns="""">5 exhibited moderate effects on antioxidant and antiglycation activities, which correlated with treatment of diabetes mellitus.