Propofol-induced rno-miR-665 targets BCL2L1 and influences apoptosis in rodent developing hippocampal astrocytes
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- 作者：Wen-Chong Sun ; Zuo-Di Liang ; Ling Pei ; lingpei49@vip.sina.com" class="auth_mail" title="E-mail the corresponding author ; lingpei49@sina.cm" class="auth_mail" title="E-mail the corresponding author
- 关键词：DMEM ; Dulbecco's modified Eagles medium ; GFAP ; glial fibrillary acidic protein antibody ; GnRH ; gonadotropin-releasing hormone ; Jak-STAT ; janus kinase-signal transducer and activator of transcription ; KEGG ; Kyoto Encyclopedia of Genes and Genomes ; miRNA ; microRNA ; GO ; gene ontology ; MTT ; 3-(4 ; 5-dimethyl-thiazol-2-yl)-2 ; 5-diphenyltetrazolium bromide ; mut ; mutant ; NC ; negative control ; PBS ; phosphate-buffered saline ; PI ; propidium iodide ; PVDF ; polyvinylidene diflouride ; qRT-PCR ; quantitative real-
- 刊名：Neurotoxicology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：51
- 期：Complete
- 页码：87-95
- 全文大小：2616 K
文摘
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Propofol exerts cytotoxic effects on immature hippocampal astrocytes via miRNAs.
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Rno-miR-665 targeted genes are mostly related to CNS development and cell fate.
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Rno-miR-665 targets anti-apoptotic BCL2L1 under caspase-3-mediated mechanism.
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Downregulation of rno-miR-665 protects astrocytes from propofol-induced apoptosis.