Heparin-binding epidermal growth factor-like growth factor (HB-EGF) induction on Snail expression during mouse decidualization
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- 作者：Xiu-Hong Zhang ; Xuan Liang ; Tong-Song Wang ; Xiao-Huan Liang ; Ru-Juan Zuo ; Wen-Bo Deng ; Zhi-Rong Zhang ; Fu-Niu Qin ; Zhen-Ao Zhao ; Zeng-Ming Yang
- 关键词：Uterus ; Decidua ; Snail ; HB-EGF ; Embryo implantation
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2013
- 出版时间：5 December, 2013
- 年：2013
- 卷：381
- 期：1-2
- 页码：272-279
- 全文大小：1238 K
文摘
Embryo implantation requires a precise synchronism between the receptive uterus and activated blastocyst and is regulated by complicated molecular networks. Although many implantation-related genes have been identified, the crosstalk among them is still unknown. Snail, a transcription repressor, plays a central role during epithelial-mesenchymal transition. Our previous study showed that Snail is highly expressed at implantation site in mouse uterus. This study was to examine how Snail is related with other implantation-related genes in mice. Uterine stromal cells were isolated from mouse uteri on day 4 of pregnancy and treated with HB-EGF. Snail was induced significantly by HB-EGF. By using specific inhibitors and siRNA, we demonstrated that HB-EGF induction on Snail expression is dependent on the EGFR-ERK-Stat3 pathway. Cox-2 was regulated by Snail. The current findings demonstrate that Snail can relate with HB-EGF, Stat3 and Cox-2 and may play a role during mouse embryo implantation and decidualization.