Percutaneous fiber-optic biosensor for immediate evaluation of chemotherapy efficacy in vivo (Part II): In vitro and in vivo characterization
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- 作者：Shu-Yu FanAuthor Vitae ; Han-Sheng ChiuAuthor Vitae ; Ding-Yi LinAuthor Vitae ; Alexandra LiaoAuthor Vitae ; Kuo-Chih Liao ; vincent1228@hotmail.com" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Fiber-optic sensor ; Non-homogeneous biomarker distribution ; In vivo monitoring ; Chemotherapy efficacy ; Apoptosis sensor
- 刊名：Sensors & Actuators: B. Chemical
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：222
- 期：Complete
- 页码：579-587
- 全文大小：3162 K
文摘
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Fiber-optic platform for non-homogeneously distributed biomarker sensing.
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FM 1-43 as optimal apoptotic activity indicator.
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Phospholipid conjugated marina blue (Mb) as optimal cell spatial distribution indicator in the vicinity of sensor probe.
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Indication of chemotherapy induced apoptotic activity by threshold value of FluoFM1-43/FluoMb.
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Signal input of personalized chemotherapy system.