Monkeypox virus induces the synthesis of less dsRNA than vaccinia virus, and is more resistant to the anti-poxvirus drug, IBT, than vaccinia virus
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- 作者：William D. Arndta ; b ; wdarndt@sandia.gov" class="auth_mail" title="E-mail the corresponding author ; Stacy D. Whitea ; b ; Stacy.White@azdhs.gov" class="auth_mail" title="E-mail the corresponding author ; Brian P. Johnsonb ; brian.p.johnson@asu.edu" class="auth_mail" title="E-mail the corresponding author ; Trung Huynha ; b ; trung.huynh@asu.edu" class="auth_mail" title="E-mail the corresponding author ; Jeffrey Liaoa ; b ; Jeffrey.liao@asu.edu" class="auth_mail" title="E-mail the corresponding author ; Heather Harringtona ; b ; heather.harrington@asu.edu" class="auth_mail" title="E-mail the corresponding author ; Samantha Cotsmireb ; Samantha.cotsmire@asu.edu" class="auth_mail" title="E-mail the corresponding author ; Karen V. Kiblerb ; Karen.kibler@asu.edu" class="auth_mail" title="E-mail the corresponding author ; Jeffrey Langlandb ; jeffrey.langland@asu.edu" class="auth_mail" title="E-mail the corresponding author ; Bertram L. Jacobsa ; b ; bjacobs@asu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Monkeypox virus ; Poxvirus pathogenesis ; dsRNA ; E3 gene ; F3 gene ; Innate immune evasion ; IBT resistance ; Poxvirus transcription ; Virulence ; Vaccinia virus
- 刊名：Virology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：497
- 期：Complete
- 页码：125-135
- 全文大小：3649 K
文摘
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Monkeypox virus produces less dsRNA than vaccinia virus.
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Monkeypox virus infection led to less accumulation of dsRNA than vaccinia virus.
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Monkeypox virus infection was eight-fold more resistant to IBT than wild-type vaccinia virus.