Lipid emulsion reverses bupivacaine-induced apoptosis of h9c2 cardiomyocytes: PI3K/Akt/GSK-3β signaling pathway
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- 作者：Danni Lva ; lvdanni19890216@163.com" class="auth_mail" title="E-mail the corresponding author ; Zhixia Baib ; zx4073354@163.com" class="auth_mail" title="E-mail the corresponding author ; Libin Yangc ; yanglibing1984@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiaohui Lia ; crystalliy@163.com" class="auth_mail" title="E-mail the corresponding author ; Xuexin Chenb ; chenxuexin2637@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lipid emulsion ; Bupivacaine ; Cardiac cytotoxicity ; mPTP ; PI3K/Akt/GSK-3β
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：42
- 期：Complete
- 页码：85-91
- 全文大小：1640 K
文摘
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BPV decreased activity of mitochondrial respiratory chain complexes.
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LE reduced apoptosis of H9C2 cardiomyocytes by suppressing mPTP opening.
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LE attenuated mPTP opening induced by BPV via increasing pGSK3β and pAkt.