Simultaneous determination of loganin, morroniside, catalpol and acteoside in normal and chronic kidney disease rat plasma by UPLC-MS for investigating the pharmacokinetics of Rehmannia glutinosa and Cornus officinalis Sieb drug pair extract
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- 作者：Min Zhao ; Jinhua Tao ; Dawei Qian ; Pei Liu ; Er-xin Shang ; Shu Jiang ; jiangshu2020@126.com" class="auth_mail" title="E-mail the corresponding author ; Jianming Guo ; Shu-lan Su ; Jin-ao Duan ; dja@njutcm.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Leyue Du
- 关键词：UPLC&ndash ; MS ; Loganin ; Morroniside ; Catalpol ; Acteoside ; Chronic kidney disease ; Rehmannia glutinosa ; Cornus officinalis ; Pharmacokinetic study
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：1009-1010
- 期：Complete
- 页码：122-129
- 全文大小：1440 K
文摘
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Doxorubicin was used to induce the chronic kidney disease rats.
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Pharmacokinetics of four constituents in Rehmannia glutinosa Libosch and Cornus officinalis Sieb drug pair were determined.
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The AUC0–t, AUC0–∞, Cmax and CL/F were significantly different.
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Factors might result in the differences were proposed.