Adverse drug reactions and organ damage: The liver
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- 作者：Anna Licata ; anna.licata@unipa.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：DILI ; Drug-induced liver injury ; ADRs ; Adverse drug reactions ; HDS ; Herbal and/or dietary supplement ; APAP ; N-acetyl-P-aminophenol ; ALF ; Acute liver failure ; NSAIDs ; Non-steroidal anti-inflammatory drugs ; AMC ; Amoxicillin&ndash ; clavulanate ; INH ; Isoniazid ; ALT ; Alanine aminotransferase ; ALP ; Alkaline phosphatase ; RUCAM ; Roussel Uclaf causality assessment method ; DIAIH ; Drug-induced autoimmune hepatitis ; NAC ; N-acetyl cysteine ; miRNAs ; MicroRNAs ; ABC ; ATP binding cassette ; Th ; T helper ; IL ; Inter
- 刊名：European Journal of Internal Medicine
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：28
- 期：Complete
- 页码：9-16
- 全文大小：626 K
文摘
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Drug induced liver injury is the most challenging acute or chronic liver disease handles by physicians.
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Drug induced liver injury depends on the interplay between drug, host and environmental risk factors.
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Drug induced liver injury DILI encompass a wide spectrum of diseases with varying clinical/histological features.
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Drug induced liver injury is an exclusion diagnosis in which clinical judgment remain essential.
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Patients with hepatocellular liver injury induced by drugs are at risk of acute liver failure.