Replacement of daily load attenuates but does not prevent changes to the musculoskeletal system during bed rest

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• 作者：Peter R. Cavanagh ; PhD DSc^a ; ^{cavanagh@uw.edu} ; Andrea J. Rice ; BS MS^a ; Sara C. Novotny ; BS MS^a ; Kerim O. Genc ; MS PhD^a ; Ricki K. Englehaupt ; RN^b ; Tammy M. Owings ; DEng^c ; Bryan Comstock ; MS^d ; Tamre Cardoso ; PhD^e ; Hakan Ilaslan^f ; Scott M. Smith^g ; Angelo A. Licata ; MD PhD^h
• 关键词：Space flight ; Bed rest ; Exercise ; Biomechanics ; Simulation ; Gravity
• 刊名：Bone Reports
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：5
• 期：Complete
• 页码：299-307
• 全文大小：680 K
• 卷排序：5

文摘

Daily loads were quantified in subjects who were then randomly assigned to control or exercise groups. Eleven subjects (5 exercise, 6 control) completed the protocol of 84-days head-down bedrest. In 2 hip regions, bone loss was significant in controls but not in exercising subjects. The exercise group retained a larger percentage ofquadriceps and gastrocnemius muscle volumes and VO2max than controls. 1x day locomotor exercise attenuates changes but does not maintain musculoskeletal or cardiovascular health during bedrest.