Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction
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- 作者：Sarah C. Edwards ; Sarah C. Higgins ; Kingston H.G. Mills ; kingston.mills@tcd.ie" class="auth_mail" title="E-mail the corresponding author
- 关键词：Experimental autoimmune encephalomyelitis ; Multiple sclerosis ; CNS inflammation ; Infection ; Bordetella pertussis ; IL-10 ; Th17 cell ; Th1 cell ; VLA-4 ; LFA-1 ; Immune regulation ; Hygiene hypothesis
- 刊名：Brain, Behavior, and Immunity
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：50
- 期：Complete
- 页码：41-46
- 全文大小：654 K
文摘
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A concurrent respiratory infection can ameliorate CNS disease in the EAE model.
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Bacterial pathogens can exert bystander suppression on autoimmunity.
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Bacterial-induced IL-10 can protect against CNS inflammation.
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IL-10 suppresses licensing of autoaggressive T cells in the lungs.